Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Shh  sonic hedgehog   (Synonyms: Hhg1)
Results	Reference
1*	J:29276 Acampora D, Mazan S, Lallemand Y, Avantaggiato V, Maury M, Simeone A, Brulet P, Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995 Oct;121(10):3279-90
1	J:181298 Alvarez-Bolado G, Paul FA, Blaess S, Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions. Neural Dev. 2012;7(1):4
1*	J:111609 Anderson RM, Stottmann RW, Choi M, Klingensmith J, Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Dev Dyn. 2006 Aug 7;235(9):2507-2520
1	J:220460 Andre P, Song H, Kim W, Kispert A, Yang Y, Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27
1*	J:19895 Ang SL, Rossant J, HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 1994 Aug 26;78(4):561-74
1	J:44143 Apelqvist A, Ahlgren U, Edlund H, Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol. 1997 Oct 1;7(10):801-4
1	J:110211 Baek JH, Hatakeyama J, Sakamoto S, Ohtsuka T, Kageyama R, Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development. 2006 Jul;133(13):2467-76
1*	J:110714 Barrionuevo F, Taketo MM, Scherer G, Kispert A, Sox9 is required for notochord maintenance in mice. Dev Biol. 2006 Jul 1;295(1):128-40
1*	J:71880 Beverdam A, Brouwer A, Reijnen M, Korving J, Meijlink F, Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice. Development. 2001 Oct;128(20):3975-86
1	J:175338 Bhattaram P, Penzo-Mendez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V, Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun. 2010;1:9
1*	J:174212 Blaess S, Bodea GO, Kabanova A, Chanet S, Mugniery E, Derouiche A, Stephen D, Joyner AL, Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei. Neural Dev. 2011;6:29
1*	J:108509 Blaess S, Corrales JD, Joyner AL, Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development. 2006 May;133(9):1799-809
1	J:266546 Brown JM, Garcia-Garcia MJ, Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics. Development. 2018 Oct 5;145(19):dev170019
1	J:36587 Bueno D, Skinner J, Abud H, Heath JK, Spatial and temporal relationships between Shh, Fgf4, and Fgf8 gene expression at diverse signalling centers during mouse development. Dev Dyn. 1996 Nov;207(3):291-9
1*	J:79514 Burke Z, Oliver G, Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm. Mech Dev. 2002 Oct;118(1-2):147
1	J:249800 Burnett JB, Lupu FI, Eggenschwiler JT, Proper ciliary assembly is critical for restricting Hedgehog signaling during early eye development in mice. Dev Biol. 2017 Oct 1;430(1):32-40
1	J:245758 Carreno G, Apps JR, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP, Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. Development. 2017 Sep 15;144(18):3289-3302
1	J:155225 Castelo-Branco G, Andersson ER, Minina E, Sousa KM, Ribeiro D, Kokubu C, Imai K, Prakash N, Wurst W, Arenas E, Delayed dopaminergic neuron differentiation in Lrp6 mutant mice. Dev Dyn. 2009 Sep 30;239(1):211-221
1	J:132152 Chamberlain CE, Jeong J, Guo C, Allen BL, McMahon AP, Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development. 2008 Mar;135(6):1097-106
1*	J:21621 Chang DT, Lopez A, von Kessler DP, Chiang C, Simandl BK, Zhao R, Seldin MF, Fallon JF, Beachy PA, Products, genetic linkage and limb patterning activity of a murine hedgehog gene. Development. 1994 Nov;120(11):3339-53
1	J:325251 Chen A, Liao S, Cheng M, Ma K, Wu L, Lai Y, Qiu X, Yang J, Xu J, Hao S, Wang X, Lu H, Chen X, Liu X, Huang X, Li Z, Hong Y, Jiang Y, Peng J, Liu S, Shen M, Liu C, Li Q, Yuan Y, Wei X, Zheng H, Feng W, Wang Z, Liu Y, Wang Z, Yang Y, Xiang H, Han L, Qin B, Guo P, Lai G, Munoz-Canoves P, Maxwell PH, Thiery JP, Wu QF, Zhao F, Chen B, Li M, Dai X, Wang S, Kuang H, Hui J, Wang L, Fei JF, Wang O, Wei X, Lu H, Wang B, Liu S, Gu Y, Ni M, Zhang W, Mu F, Yin Y, Yang H, Lisby M, Cornall RJ, Mulder J, Uhlen M, Esteban MA, Li Y, Liu L, Xu X, Wang J, Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Cell. 2022 May 12;185(10):1777-1792.e21
1	J:183920 Chen J, Lai F, Niswander L, The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15;26(8):803-15
1	J:151923 Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang PT, Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 2009 Aug 15;23(16):1910-28
1	J:181474 Christ A, Christa A, Kur E, Lioubinski O, Bachmann S, Willnow TE, Hammes A, LRP2 Is an Auxiliary SHH Receptor Required to Condition the Forebrain Ventral Midline for Inductive Signals. Dev Cell. 2012 Feb 14;22(2):268-78
1	J:101731 Cooper AF, Yu KP, Brueckner M, Brailey LL, Johnson L, McGrath JM, Bale AE, Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development. 2005 Oct;132(19):4407-17
1	J:83530 Dakubo GD, Wang YP, Mazerolle C, Campsall K, McMahon AP, Wallace VA, Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development. Development. 2003 Jul;130(13):2967-80
1	J:190013 Dennis JF, Kurosaka H, Iulianella A, Pace J, Thomas N, Beckham S, Williams T, Trainor PA, Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. PLoS Genet. 2012 Oct;8(10):e1002927
1	J:294824 Dias A, Lozovska A, Wymeersch FJ, Novoa A, Binagui-Casas A, Sobral D, Martins GG, Wilson V, Mallo M, A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation. Elife. 2020 Jun 29;9:e56615
1*	J:16386 Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, McMahon AP, Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
1*	J:51127 Epstein DJ, McMahon AP, Joyner AL, Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms. Development. 1999 Jan;126(2):281-92
1*	J:72022 Esni F, Johansson BR, Radice GL, Semb H, Dorsal pancreas agenesis in N-cadherin- deficient mice. Dev Biol. 2001 Oct 1;238(1):202-12
1	J:297740 Eto H, Kishi Y, Yakushiji-Kaminatsui N, Sugishita H, Utsunomiya S, Koseki H, Gotoh Y, The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon. Nat Commun. 2020 Nov 11;11(1):5709
1	J:89589 Fagman H, Grande M, Gritli-Linde A, Nilsson M, Genetic deletion of sonic hedgehog causes hemiagenesis and ectopic development of the thyroid in mouse. Am J Pathol. 2004 May;164(5):1865-72
1	J:106035 Ferrante MI, Zullo A, Barra A, Bimonte S, Messaddeq N, Studer M, Dolle P, Franco B, Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification. Nat Genet. 2006 Jan;38(1):112-7
1*	J:41809 Filosa S, RiveraPerez JA, Gomez AP, Gansmuller A, Sasaki H, Behringer RR, Ang SL, goosecoid and HNF-3 beta genetically interact to regulate neural tube patterning during mouse embryogenesis. Development. 1997 JUL;124(14):2843-2854
1	J:191791 Garrido-Allepuz C, Gonzalez-Lamuno D, Ros MA, Sirenomelia phenotype in bmp7;shh compound mutants: a novel experimental model for studies of caudal body malformations. PLoS One. 2012;7(9):e44962
1	J:140315 Geng X, Speirs C, Lagutin O, Inbal A, Liu W, Solnica-Krezel L, Jeong Y, Epstein DJ, Oliver G, Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008 Aug;15(2):236-47
1*	J:31336 Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP, Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 1996 Feb 1;10(3):301-12
1*	J:47700 Greene ND, Gerrelli D, Van Straaten HW, Copp AJ, Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects. Mech Dev. 1998 Apr;73(1):59-72
1	J:299735 Han L, Chaturvedi P, Kishimoto K, Koike H, Nasr T, Iwasawa K, Giesbrecht K, Witcher PC, Eicher A, Haines L, Lee Y, Shannon JM, Morimoto M, Wells JM, Takebe T, Zorn AM, Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Nat Commun. 2020 Aug 27;11(1):4158
1	J:243204 Han L, Xu J, Grigg E, Slack M, Chaturvedi P, Jiang R, Zorn AM, Osr1 functions downstream of Hedgehog pathway to regulate foregut development. Dev Biol. 2017 Jul 01;427(1):72-83
1	J:220655 Harmacek L, Watkins-Chow DE, Chen J, Jones KL, Pavan WJ, Salbaum JM, Niswander L, A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice. Dev Neurobiol. 2014 May;74(5):483-97
1	J:193109 Hayes L, Ralls S, Wang H, Ahn S, Duration of Shh signaling contributes to mDA neuron diversity. Dev Biol. 2013 Feb 1;374(1):115-26
1*	J:66532 Hecksher-Sorensen J, Sharpe J, 3D confocal reconstruction of gene expression in mouse. Mech Dev. 2001 Jan;100(1):59-63
1	J:245009 Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodovar C, Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 2017 Mar 06;8:14583
1*	J:241009 Himmelstein DS, Cajigas I, Bi C, Clark BS, Van Der Voort G, Kohtz JD, SHH E176/E177-Zn2+ conformation is required for signaling at endogenous sites. Dev Biol. 2017 Apr 15;424(2):221-235
1	J:301496 Hiraga K, Inoue YU, Asami J, Hotta M, Morimoto Y, Tatsumoto S, Hoshino M, Go Y, Inoue T, Redundant type II cadherins define neuroepithelial cell states for cytoarchitectonic robustness. Commun Biol. 2020 Oct 15;3(1):574
1	J:199287 Holtz AM, Peterson KA, Nishi Y, Morin S, Song JY, Charron F, McMahon AP, Allen BL, Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development. 2013 Aug;140(16):3423-34
1*	J:119664 Houde C, Dickinson RJ, Houtzager VM, Cullum R, Montpetit R, Metzler M, Simpson EM, Roy S, Hayden MR, Hoodless PA, Nicholson DW, Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev Biol. 2006 Dec 15;300(2):523-33
1	J:143538 Hu D, Marcucio RS, Unique organization of the frontonasal ectodermal zone in birds and mammals. Dev Biol. 2009 Jan 1;325(1):200-10
1	J:227069 Huang J, Liu Y, Filas B, Gunhaga L, Beebe DC, Negative and positive auto-regulation of BMP expression in early eye development. Dev Biol. 2015 Nov 15;407(2):256-64
1	J:122547 Huang X, Litingtung Y, Chiang C, Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord. Development. 2007 Jun;134(11):2095-105
1	J:86437 Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV, Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003 Nov 6;426(6962):83-7
1*	J:106931 Isono K, Nemoto K, Li Y, Takada Y, Suzuki R, Katsuki M, Nakagawara A, Koseki H, Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol. 2006 Apr;26(7):2758-71
1	J:252110 Iulianella A, Sakai D, Kurosaka H, Trainor PA, Ventral neural patterning in the absence of a Shh activity gradient from the floorplate. Dev Dyn. 2018 Jan;247(1):170-184
1	J:106015 Jeong Y, El-Jaick K, Roessler E, Muenke M, Epstein DJ, A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers. Development. 2006 Feb;133(4):761-72
1*	J:104200 Jin JZ, Gu S, McKinney P, Ding J, Expression and functional analysis of Tgif during mouse midline development. Dev Dyn. 2006 Feb;235(2):547-53
1	J:104870 Jin O, Harpal K, Ang SL, Rossant J, Otx2 and HNF3beta genetically interact in anterior patterning. Int J Dev Biol. 2001;45(1):357-65
1	J:146200 Joksimovic M, Yun BA, Kittappa R, Anderegg AM, Chang WW, Taketo MM, McKay RD, Awatramani RB, Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci. 2009 Feb;12(2):125-31
1*	J:79831 Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT, Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec;129(24):5753-65
1*	J:79898 Kochilas L, Merscher-Gomez S, Lu MM, Potluri V, Liao J, Kucherlapati R, Morrow B, Epstein JA, The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. Dev Biol. 2002 Nov 1;251(1):157-66
1	J:52397 Koebbe MJ, Golden JA, Bennett G, Finnell RH, Mackler SA, Effects of prenatal cocaine exposure on embryonic expression of sonic hedgehog. Teratology. 1999 Jan;59(1):12-9
1*	J:60432 Kolle G, Georgas K, Holmes GP, Little MH, Yamada T, CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech Dev. 2000 Feb;90(2):181-93
1*	J:316551 Kwon YR, Jeong MH, Leem YE, Lee SJ, Kim HJ, Bae GU, Kang JS, The Shh coreceptor Cdo is required for differentiation of midbrain dopaminergic neurons. Stem Cell Res. 2014 Sep;13(2):262-74
1	J:225071 Law KK, Makino S, Mo R, Zhang X, Puviindran V, Hui CC, Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling. PLoS One. 2012;7(11):e50193
1*	J:71832 Lee CS, Buttitta L, Fan CM, Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11347-52
1*	J:41684 Lee J, Platt KA, Censullo P, Ruiz i Altaba A, Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development. 1997 Jul;124(13):2537-52
1	J:57317 Li H, Arber S, Jessell TM, Edlund H, Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet. 1999 Sep;23(1):67-70
1	J:49604 Litingtung Y, Lei L, Westphal H, Chiang C, Sonic hedgehog is essential to foregut development [see comments]. Nat Genet. 1998 Sep;20(1):58-61
1	J:343069 Lodge EJ, Barrell WB, Liu KJ, Andoniadou CL, The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development. J Anat. 2023 Oct 4;
1	J:139252 Lokmane L, Haumaitre C, Garcia-Villalba P, Anselme I, Schneider-Maunoury S, Cereghini S, Crucial role of vHNF1 in vertebrate hepatic specification. Development. 2008 Aug;135(16):2777-86
1	J:257916 Lupu FI, Burnett JB, Eggenschwiler JT, Cell cycle-related kinase regulates mammalian eye development through positive and negative regulation of the Hedgehog pathway. Dev Biol. 2018 Feb 1;434(1):24-35
1	J:79457 Ma Y, Erkner A, Gong R, Yao S, Taipale J, Basler K, Beachy P, Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched. Cell. 2002 Oct 4;111(1):63
1*	J:314133 Marczenke M, Sunaga-Franze DY, Popp O, Althaus IW, Sauer S, Mertins P, Christ A, Allen BL, Willnow TE, GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium. Development. 2021 Nov 1;148(21):dev200080
1*	J:28010 Marti E, Takada R, Bumcrot DA, Sasaki H, McMahon AP, Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development. 1995 Aug;121(8):2537-47
1	J:100594 Martin M, Gallego-Llamas J, Ribes V, Kedinger M, Niederreither K, Chambon P, Dolle P, Gradwohl G, Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol. 2005 Aug 15;284(2):399-411
1	J:121554 Martinelli DC, Fan CM, Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 2007 May 15;21(10):1231-43
1	J:253802 Matsumaru D, Murashima A, Fukushima J, Senda S, Matsushita S, Nakagata N, Miyajima M, Yamada G, Systematic stereoscopic analyses for cloacal development: The origin of anorectal malformations. Sci Rep. 2015 Sep 10;5:13943
1	J:122005 Mavrakis KJ, Andrew RL, Lee KL, Petropoulou C, Dixon JE, Navaratnam N, Norris DP, Episkopou V, Arkadia Enhances Nodal/TGF-beta Signaling by Coupling Phospho-Smad2/3 Activity and Turnover. PLoS Biol. 2007 Mar 6;5(3):e67
1	J:181153 Mesbah K, Rana MS, Francou A, van Duijvenboden K, Papaioannou VE, Moorman AF, Kelly RG, Christoffels VM, Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis. Hum Mol Genet. 2012 Mar 15;21(6):1217-29
1*	J:104611 Moore-Scott BA, Manley NR, Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs. Dev Biol. 2005 Feb 15;278(2):323-35
1*	J:51701 Motoyama J, Heng H, Crackower MA, Takabatake T, Takeshima K, Tsui LC , Hui C, Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis. Mech Dev. 1998 Nov;78(1-2):81-4
1*	J:84056 Motoyama J, Milenkovic L, Iwama M, Shikata Y, Scott MP, Hui CC, Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev Biol. 2003 Jul 1;259(1):150-61
1	J:193395 Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK, The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Cell. 2013 Jan 17;152(1-2):210-23
1*	J:72911 Murdoch JN, Doudney K, Paternotte C, Copp AJ, Stanier P, Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. Hum Mol Genet. 2001 Oct 15;10(22):2593-601
1	J:289632 Nagai MH, Xavier VPS, Gutiyama LM, Machado CF, Reis AH, Donnard ER, Galante PAF, Abreu JG, Festuccia WT, Malnic B, Depletion of Ric-8B leads to reduced mTORC2 activity. PLoS Genet. 2020 May;16(5):e1008255
1	J:38554 Nagai T, Aruga J, Takada S, Gunther T, Sporle R, Schughart K , Mikoshiba K, The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation. Dev Biol. 1997 Feb 15;182(2):299-313
1	J:273907 Nandadasa S, Kraft CM, Wang LW, O'Donnell A, Patel R, Gee HY, Grobe K, Cox TC, Hildebrandt F, Apte SS, Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis. Nat Commun. 2019 Feb 27;10(1):953
1	J:147574 Norman RX, Ko HW, Huang V, Eun CM, Abler LL, Zhang Z, Sun X, Eggenschwiler JT, Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet. 2009 May 15;18(10):1740-54
1	J:90053 Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe PT, A dual role for Ikk alpha in tooth development. Dev Cell. 2004 Feb;6(2):219-27
1*	J:157907 Okae H, Iwakura Y, Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice. Dev Dyn. 2010 Apr;239(4):1089-101
1	J:92241 Parrish M, Ott T, Lance-Jones C, Schuetz G, Schwaeger-Nickolenko A, Monaghan AP, Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality. Mol Cell Biol. 2004 Aug;24(16):7102-12
1	J:147584 Patterson VL, Damrau C, Paudyal A, Reeve B, Grimes DT, Stewart ME, Williams DJ, Siggers P, Greenfield A, Murdoch JN, Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet. 2009 May 15;18(10):1719-39
1	J:188279 Peng C, Li N, Ng YK, Zhang J, Meier F, Theis FJ, Merkenschlager M, Chen W, Wurst W, Prakash N, A Unilateral Negative Feedback Loop Between miR-200 microRNAs and Sox2/E2F3 Controls Neural Progenitor Cell-Cycle Exit and Differentiation. J Neurosci. 2012 Sep 19;32(38):13292-13308
1	J:204743 Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE, Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature. 2013 Aug 29;500(7464):589-92
1	J:316612 Peterson KA, Nishi Y, Ma W, Vedenko A, Shokri L, Zhang X, McFarlane M, Baizabal JM, Junker JP, van Oudenaarden A, Mikkelsen T, Bernstein BE, Bailey TL, Bulyk ML, Wong WH, McMahon AP, Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes Dev. 2012 Dec 15;26(24):2802-16
1*	J:88784 Petryk A, Anderson RM, Jarcho MP, Leaf I, Carlson CS, Klingensmith J, Shawlot W, O'Connor MB, The mammalian twisted gastrulation gene functions in foregut and craniofacial development. Dev Biol. 2004 Mar 15;267(2):374-86
1*	J:31131 Pfaff SL, Mendelsohn M, Stewart CL, Edlund T, Jessell TM, Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell. 1996 Jan 26;84(2):309-20
1	J:238372 Rankin SA, Han L, McCracken KW, Kenny AP, Anglin CT, Grigg EA, Crawford CM, Wells JM, Shannon JM, Zorn AM, A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification. Cell Rep. 2016 Jun 28;16(1):66-78
1	J:313346 Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM, Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. Elife. 2021 Oct 13;10:e69288
1*	J:103820 Reiter JF, Skarnes WC, Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev. 2006 Jan 1;20(1):22-7
1*	J:160812 Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, Cayuso J, Tozer S, Yang LL, Novitch B, Marti E, Briscoe J, Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev. 2010 Jun 1;24(11):1186-200
1	J:144016 Ribes V, Le Roux I, Rhinn M, Schuhbaur B, Dolle P, Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways. Development. 2009 Feb;136(4):665-76
1	J:104523 Ribes V, Wang Z, Dolle P, Niederreither K, Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling. Development. 2006 Jan;133(2):351-61
1	J:166040 Rocha PP, Scholze M, Bleiss W, Schrewe H, Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development. 2010 Aug;137(16):2723-31
1*	J:50582 Roebroek AJ, Umans L, Pauli IG, Robertson EJ, van Leuven F, Van de Ven WJ , Constam DB, Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. Development. 1998 Dec;125(24):4863-76
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